Clinical Perspective: Neurological Disorders

Hereditary neurological diseases are often very aggressive conditions that reduce the quality of life of the dog significantly. Some of these conditions are so aggressive that euthanasia is the only option as symptoms progress. Fortunately most hereditary neurological disorders are quite rare.

MyDogDNA® contributes to the understanding of the breed history and diversity of the Finnish national dog

This week the Journal of Animal Breeding and Genetics published a study regarding the impact of breed history on the genetic diversity in Finnish and Nordic Spitz. The study was conducted in collaboration between Genoscoper Laboratories, breed enthusiasts and the department of Environmental and Biological Sciences, University of Eastern Finland. Besides combining traditional pedigree analysis and genotyping in a unique way, the work is also a rare example of citizen science.

The dog, the DNA test, and the scientist – a reflection on four years of panel screening

When we first launched the MyDogDNA® (Optimal Selection™ in the United States) DNA test in 2013, we took a giant leap into unexplored territory. To be honest (and we Finns typically are), pioneering a whole new way of thinking about dog DNA testing was not the easiest thing to do. 

If you had been able to listen in on the conversations at our laboratory office back then, you would probably have heard us asking ourselves questions such as: 

MyDogDNA Breed Data: English Cocker Spaniel

The English Cocker Spaniel is a small-sized gun dog that is mainly used for hunting, dog sports and dog shows. The breed is divided into show and working lines that have distinct characteristics. In this article, we focus on English Cocker Spaniel breed data created by the MyDogDNA testing panel, focusing especially on genetic diversity.

The Dog’s Genetic Size – The Strong and Weak Size Markers

Understanding canine genetic size may be an important tool in the future, for instance, in planning of individual care, such as weight control. Previously we introduced the new size markers added to the MyDogDNA test panel. In this blog article, we will give a deeper insight into the effects of these markers.

Understanding the Dog's Genetic Size Facilitates Planning Individual Care and Weight Control

MyDogDNA has now added four new size associated genetic markers called GHR1, GHR2, HMGA2, STC2and a test for breed-defining chondrodysplasia to the test panel. These markers, together with the previously reported size associated markers in IGF1 and IGF1R give more information on the dog size, supporting finer prediction of the genetic size of a dog.

MyDogDNA Breed Data: Irish Soft Coated Wheaten Terrier

The Irish Soft Coated Wheaten is a wheat coloured, middle-sized, terrier breed. In this article, we focus on Irish Soft Coated Wheaten Terrier breed data collected with the MyDogDNA test panel, as well as on how to use this data in practice.

Rare Coat Length Variants Are a Part of MyDogDNA2016 Test Content

Hair length is an important morphological trait that varies between different dog breeds. The fibroblast growth factor 5 (FGF5) is the only known gene leading to long-haired phenotype in mammals. Long hair is inherited as a simple recessive trait.

MyDogDNA® 2016 Test Content

The hard work of our R&D has recently resulted in the new and even more comprehensive MyDogDNA® 2016 test panel that is available in our web shop. For dogs that have already been tested with MyDogDNA PASS, MyDogDNA LITE or MyDogDNA 2015 packages, we offer the possibility for cost-efficient upgrade for purchasing the new test content. The upgrade requires a new sample.

Clinical perspective: Bleeding disorders

Many different types of hereditary bleeding disorders have been encountered in dogs, some of which are quite common in certain breeds (Table 1). Most of these cause spontaneously only mild bleeding, such as nosebleeds or bleeding of the gums. However, many bleeding disorders can cause excessive, even life-threatening, bleeding after surgery or trauma.

Table 1. The occurrence of certain common bleeding disorders in certain breeds

New test content for Labrador Retrievers and Jack Russell Terriers

Genetic tests for mutations causing Congenital Myasthenic Syndrome in Labrador Retrievers and Jack Russell Terriers are now available in the MyDogDNA 2016 test panel. The disorder is considered severe, typically with an early onset of symptoms. See a more detailed description below.

New study on the canine breed disease heritage gives a comprehensive insight into the breed distribution of disease related genetic risk variants

The MyDogDNA research team of Genoscoper Laboratories Oy, Finland, has in collaboration with scientists from the University of Helsinki, Finland, and University of Pennsylvania, Philadelphia, USA, published the results from the most comprehensive investigation into the canine breed disease heritage to date.

Soon in the MyDogDNA test panel: Developmental Syndrome in Wire Fox Terriers

The genetic cause for a previously undescribed skeletal syndrome in Wire Fox Terriers was recently revealed in a publication by the canine genetics research group at the University of Helsinki. Genoscoper will soon be the first laboratory in the world to offer the genetic test for this condition in the MyDogDNA test panel.

Test soon available for Dental hypomineralization in Border Collies

The canine genetics research group at the University of Helsinki published a study in May revealing the genetic causes for three hereditary disorders. With the novel gene discoveries the research group was able to identify the genetic causes for hyperostosis in Terrier breeds, dental hypomineralization in Border Collie, and previously undescribed skeletal syndrome in Wire Fox Terriers.

Clinical perspective: the MDR1 mutation

I work as an on-duty veterinarian providing emergency care for pets. My patients are often seriously ill and require intensive medical care; decisions have to be made rapidly. For many of my patients, adverse reactions in response to drugs could potentially be severe. As a veterinarian, I would prefer that at least each of my Collie, Australian Shepherd and Shetland Sheepdog patients would be tested for MDR1 mutation before starting treatment. In this article I will tell you why.