Test soon available for Dental hypomineralization in Border Collies

The canine genetics research group at the University of Helsinki published a study in May revealing the genetic causes for three hereditary disorders. With the novel gene discoveries the research group was able to identify the genetic causes for hyperostosis in Terrier breeds, dental hypomineralization in Border Collie, and previously undescribed skeletal syndrome in Wire Fox Terriers. These discoveries will contribute directly to the well-being of different breeds along with the genetic tests developed to identify the carriers of the genetic defects. These tests will soon be available as part of the MyDogDNA test panel.

Further information on the research and discoveries:




Introduction to Dental hypomineralization in Border Collies

In brief:

Dental hypomineralization is a hereditary dental disease that is caused by abnormal mineralization of teeth during dental development. The disease causes abnormal tooth wear, pulpitis and tooth loss. The disorder has been described in Border Collies. The genetic defect is estimated to be relatively common within the breed with approximately 11% of the breed population being carriers. The mode of inheritance is autosomal recessive.

Clinical overview:

The disorder causes brownish dental discolouration and abnormal wear of teeth. As the teeth wear, the biting surfaces of the teeth are coloured dark brown and the enamel layer is coloured light brown. The disorder causes severe tooth wear leading to pulp exposure, chronic inflammation of the pulp and pulpal necrosis. Histologically, dentin of affected dogs has an abnormal structure and the enamel can be slightly hypoplastic.

Clinical signs:

  • abnormal tooth wear
  • pulpitis
  • teeth loss
  • severe tooth hypomineralization